Best D-Mannose Brands For UTI & Overall Health in 2024

Antibiotic resistance is becoming a major problem. Strains of bacteria that cause various health conditions, some of them very serious, no longer respond to antibiotics, which has been catastrophic for many.

There are alternatives to antibiotics which can help to prevent more strains of bacteria following suit. D-mannose is one of them, specifically when it comes to UTI. 

If you've ever had UTI, you know that it's no fun at all. 

Recurrent UTI is the worst.

Taking antibiotics constantly wreaks havoc on your gut. Your good bacteria is destroyed along with the bad, leaving your immune system weak and your digestive system prone to unwanted issues.

More on this in a bit...

When it comes to supplements, d-mannose is lesser-known, but it has some great benefits even beyond UTI, and is all natural. We've gone through dozens of d-mannose reviews so that you don't have to.

Our favorite d-mannose brand is Bulk Supplements D-Mannose Powder. Read on to learn more about this humble, yet noble supplement.

Product Details
1. Bulk Supplements Pure D-Mannose Powder (1kg)

Maintains Digestive Health

  • Pure, No Fillers
  • Sugar Substitute
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2. Harmony D-Mannose

Fights Off Infections

  • Contains Hibiscus
  • Comes In Veggie Caps
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3. Divine Bounty D-Mannose Capsules

Helps Remove Bacteria

  • Promotes Urination
  • Relieves Bloating
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4. Zazzee Naturals D-Mannose Capsules

Budget Friendly

  • Free From Allergens
  • Non-GMO
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5. Now D-Mannose 500mg

Good But Contains Fillers

  • Lab Tested
  • Easy To Swallow
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Best D-Mannose Supplement Reviews

1. Bulk Supplements Pure D-Mannose Powder 

Our Verdict: Best D-Mannose Powder

Bulk Supplements Pure D-Mannose Powder

If you are looking for pure d-mannose without any fillers, binder, and in powder form, Bulk Supplements D-Mannose Powder is a great option. It's tested for purity and quality so you know you are getting a good product.

It comes in bulk which is great if you are prone to recurrent UTI or want to use it to improve and maintain digestive health.

Although packaged and distributed from Nevada, the d-mannose comes from China and is extracted from corn glucose. While this is not necessarily a bad thing, corn is often sprayed with pesticides and/or is genetically modified.

There is nothing saying that this supplement is non-GMO or organic but it is tested for safety.


  • Free from soy, dairy, yeast, gluten or any other additives
  • Tested for purity and safety
  • Can be used as a sweetener in coffee and tea
  • 500 servings of 1 tbsp per 2.2 lb. bag
  • Comes in 2.2lb (1kg), 11lb (5kg), 55lb (25kg) or smaller options of 100g to 500g


  • Sourced from China
  • Extracted from corn glucose

2. Harmony D-Mannose

Harmony D-Mannose

Our Verdict: Best D-Mannose for UTI

Harmony combines d-mannose and hibiscus to fight off infections. In addition to combating UTI, the hibiscus makes this supplement a great antioxidant supplement too.

If just plain d-mannose doesn't do it for you, this supplement might. It's free from all binders and fillers except for rice extract and uses veggie caps. It also comes from the USA.

To get the full dose of 800mg of d-mannose and 200mg of hibiscus, you need to take 2 tablets and with only 60 capsules per bottle and being priced higher than other supplements already can make it tough to buy on a tight budget.


  • Contains hibiscus
  • Free from binders and fillers (veggie cap and rice extracts
  • Free from common allergens (wheat, gluten, dairy)
  • Cruelty-free


  • Can be expensive
  • Only 30 servings per bottle

3. Divine Bounty D-Mannose Capsules

Divine Bounty D-Mannose Capsules

Our Verdict: Most Potent Capsule

Divine Bounty combines d-mannose with cranberry juice powder and dandelion extract. These additional ingredients help to remove bacteria and promote urination to relieve bloating as well.

Each capsule contains 600mg of d-mannose making it one of the more potent options. With the recommended dose you will get 60 servings so this supplement will last you a while.

It's free from all binders and fillers so you can be assured of a pure supplement aside from the veggie capsule.

NOTE: If you have a ragweed allergy you should avoid this supplement due to the dandelion extract.


  • No binders or fillers whatsoever
  • Made in the US in an FDA approved facility and GMP certified
  • The recommended dose is 2 capsules per day
  • Contains dandelion extract and cranberry juice powder


  • Not suitable for those with ragweed allergy

4. Zazzee Naturals D-Mannose Capsules

Zazzee D-Mannose 180 Veggie Capsules, 1000 mg per Serving, Pure, Potent and Fast-Acting, Extra Strength Dosage, Vegan, Non-GMO and All-Natural

Our Verdict: Best Budget Buy (Capsules)

Zazzee Naturals provides a budget-friendly option if you prefer not to take powder with 180 capsules each containing 500mg of d-mannose.

It's free from allergens and non-GMO.

It does, however, contain additives like magnesium stearate, but this supplement is entirely plant-based.


  • Non-GMO
  • Made in the U.S in an FDA approved facility and is GMP certified
  • Free from yeast, wheat, gluten, soy, fish, egg, dairy, and nuts
  • 90 servings per bottle at the recommended dose


  • Contains additives (magnesium stearate, cellulose)

5. Now D-Mannose 500mg

Now D-Mannose 500mg

Our Verdict: Alternative Budget Buy

These D-Mannose capsules from Now is easy to swallow and you can rest assured that they are of good quality as they are lab tested. One capsule contains 500mg of d-mannose.

You can choose between 120 capsules or 240. If you struggle to swallow capsules, Now also has a powder version.

The serving size is 3 capsules which means you will go through the bottle quicker and if you prefer to steer clear of fillers, this supplement is not for you.


  • Free from dairy, eggs, nuts, soy, and gluten
  • Kosher, halal, vegan
  • Non-GMO
  • Lab tested and GMP (good manufacturing practices) certified
  • 40 servings per bottle (120 caps) if you take 3 tablets


  • One full serving (1.5g) is 3 capsules
  • Contains fillers (magnesium stearate, silica, stearic acid, rice flour)

What is the Best D-Mannose to Buy?

tablets in a case

There are a few things to consider when it comes to which form is best for you.

Do you respond better to plain d-mannose or does your body respond better to added ingredients like cranberry extract, for example?

If you are vegan or vegetarian there are certain things in supplements that you need to steer clear of.

Gelatin is one of the most common animal products in supplements. It's usually used to make the soft gel capsules so make sure when you buy capsules that they are made from vegetable cellulose. If you prefer to stay away from binders, fillers, and other additives, be sure to check the ingredients list.

Because d-mannose is naturally sweet, there is no need for added sugar. But if you do prefer flavored powders it is possible to find them without added sugar—just check the ingredients first.

What is D-Mannose?

D-mannose is actually a type of sugar that is found most abundantly in cranberries, blueberries, peaches, oranges, pineapples, apple, and even a few veggies like green beans and broccoli.

It's similar to glucose but unlike glucose, d-mannose doesn't raise your blood sugar levels. This is why it may even be useful to you as a sweetener. Let's check out the other things that make d-mannose different from other forms of sugar.

The Benefits of D-Mannose

Clears UTI

Although not everyone will respond the same way. Most people find that d-mannose treats UTI (urinary tract infection) very quickly which is definitely a good thing and not just because it's uncomfortable.

If left untreated or if treatment takes long it can spread to the kidneys and cause a lot of problems. Symptoms usually include painful urination, blood in the urine, feeling the constant need to urinate despite just doing so and when you do go, you only urinate a little.

UTI occurs in women more than men simply because of the difference in anatomy. The bacteria have a shorter distance to travel in women making it easier for the bacteria to get into the bladder.

The most common cause is e.coli. The bacteria bind to d-mannose rather than the walls of the bladder and are then transported out of your bladder along with the d-mannose when you pee.

A dose of 2g works as well as 50mg of nitrofurantoin. For most people, the infection will be gone within 3 days or so. Taking a maintenance dose can help to prevent recurring UTI.

Strengthens Your Immune System

Since it helps your body to get rid of infections, there will be less inflammation. Chronic inflammation runs your immune system down.

It's not only pathogens that we eat, but the constant slew of pesticides, harsh chemicals in our personal care products, pollution, and stress that also create inflammation. D-mannose gives the body a fighting chance to combat these things since it's one less thing for it to divert resources to.

Although there are tests still to be conducted in humans for these, results have been promising for the suppression of both type 1 diabetes and asthmatic lung inflammation (in mice).

Should you have a chronic or autoimmune disease, you should speak to your doctor first before trying to treat it on your own using d-mannose since we are very different from mice.

Improves Gut Health

Despite getting rid of harmful bacteria such as e.coli and even salmonella, d-mannose actually helps the healthy bacteria in our gut by acting as a prebiotic (feeds good bacteria) and by lowering inflammation in the gut. 

Even probiotics help, but sometimes aren't enough, so this is where the best vegan enzymes come in to do the job.

This may be helpful for those struggling with IBS (irritable bowel syndrome), IBD (irritable bowel disease), or anyone who struggles with digestive issues.

Side Effects of D-Mannose

There are very few side effects, but when they do occur, it's usually due to very large doses which results in an upset stomach. You can consume a considerable amount of it. To combat UTI, you can take 4.5g per day without side effects for most people.

You will quickly notice when a dose is too large for you.

D-mannose may not be for everyone. There have been a few reports of people who found that it did raise their glucose levels. Not everyone will experience that and it may be that the supplements used had added glucose or sucrose or even lactose. But if you are diabetic, first speak to your doctor.

As with many natural foods, you can eat them throughout your pregnancy in normal food quantities, but when it comes to medicinal quantities they may not be safe. If you are pregnant or breastfeeding, speak to your doctor before using d-mannose medicinally.

For preggies, I'm sure even your doctor would agree that vegan prenatal vitamins are perfect for your growing tummy. ;)

Your doctor will be able to advise you based on your medical history, allergens, etc.

What Is the Best Way to Take It?

As you saw, you get capsules and powders. Neither way is better than the other. It depends on what works for you. The powder is a little more versatile in that you can add it to tea, juice, coffee, put it over your cereal, or simply mix it with water.

The recommended dose will be on the supplement label.

It's easy to take. Tasty; if you have a bit of a sweet tooth, and healing. D-mannose could be just what you need if you are tired of constant infections, antibiotics, and spending time and money going to the doctor all the time.

Having said that, if you do have a severe UTI or home-treatment is not working, you should see your doctor for medical treatment.

Our Top Picks for Best D-Mannose Supplement

If you have tried d-mannose, please let us know if it worked for you!

Last Updated on May 30, 2023

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