Dr. Jekyll & Mr. Hyde Pre Workout Reviews - Which is Best For You & How Do They Compare?

The first thing that comes to mind when you hear the name of these two pre workouts is the classic movie – Dr. Jekyll and Mr. Hyde.

The former a superhero doctor, and the latter a villain.

Well, I don’t know if ProSupps got their inspiration from the movie, but it sure sets it apart from other cliche pre workout names. Plus, it actually fits into the strengths of these two products in a way.

Dr. Jekyll being the cool one with low stimulants and solid muscle pump, while Mr. Hyde is the stim-packed pre workout for stimulant freaks.

Many people have wondered which one’s best and if they can mix up Dr. Jekyll and Mr. Hyde in their training routine.

In this article, I’ll be making not only a Dr. Jekyll pre workout review or Mr. Hyde pre-workout review, but a look at both of them side-by-side.

They seem to go well together naturally, don’t they? :)

Without further ado, let’s get into the Jekyll and Hyde pre workout review.

General Info About ProSupps Supplements

ProSupps is a trusted global brand in the world of sports nutrition products. They started off as a small group of bodybuilders who wanted to make products that tapped into exactly what athletes, bodybuilders, and fitness fanatics feel and want.

In their words, “We were a small group of dudes groomed by iron, that were tired of sifting through the sea of sports nutrition products, built by people behind desks and not behind squat racks.”

Sure enough, they make products that give their customers just what they need through innovation and outstanding quality. If you are in doubt, Dr. Jekyll and Mr. Hyde pre workouts have gone through about two-three (2-3) updated versions.

Hence, the current formula, Dr. Jekyll Nitro X and Mr. Hyde Nitro X, which I’ll be giving you a review on in a bit.

Asides their two flagship products, they make other fitness products, like BCAAs, whey protein, carnitine; typically fitness related supplements.

Dr. Jekyll and Mr. Hyde come in several flavors, which I’ll reveal later, but for this review, we’ll take the watermelon flavor of both products for a spin.

Dr. Jekyll & Mr. Hyde Pre Workout Overview

Dr. Jekyll and Mr. Hyde are two unique pre workout products with their own special abilities. 

One thing these two have in common, though, is their delicious and flavorful taste.

If you feel you don’t need any caffeine but want muscle pumps, focus and energy, then go for stim-free Dr. Jekyll.

Jekyll is a low-stim PWO that gives you muscle pumps and endurance with very little caffeine content. I mean, so low you won’t feel any jitters or crash after training, but too low to drag you down to the gym.

Dr. Jekyll Nitro X replaces creatine nitrate and gamma-aminobutyric acid (Gaba) with creatine hydrochloride and theacrine. 

Not to worry, I’ll talk about the ingredients later...

Dr. Jekyll Pre Workout Features:

  • Boosts muscle strength and endurance
  • Low caffeine content with muscle pumps
  • Good for workouts during the day or at night
  • No proprietary blend
  • Vegan-friendly and gluten-free
  • Has four (4) delicious flavors: Lollipop Punch, Pixie Dust, What-O-
  • Melon (Watermelon) and Blue Razz Popsicle

Mr. Hyde, on the other hand, is like the crack of the pre workout world. One scoop is packed with so much caffeine (410mg) that it will make you hit the gym like The Hulk, as long as you can stand the caffeine hit. 

Whichever way you go, you shouldn’t be surprised if you get a crash or jitters from using Mr. Hyde.

The latest version, Mr. Hyde NitroX completely gets rid of two ingredients and replaces some others with a better version of the same substance.

However, just like Dr. Jekyll, Mr. Hyde has a different version – Mr. Hyde Icon. It is also packed with stimulants, but with even more pumps, endurance and better recovery.

Finally, Dr. Jekyll and Mr. Hyde are both vegan-friendly and gluten-free. If you were wondering, the creatine is from an artificial source, so it doesn’t contain dairy.

Mr. Hyde Pre Workout Features:

  • Blows your energy levels through the roof
  • Mild strength and endurance boost
  • No proprietary blend
  • Vegan certified and gluten-free
  • A ton of flavors to choose from (10): Pixie Dust, Blue Razz Popsicle,
  • Cherry Popsicle, Cotton Candy, Orange Slice, Lollipop Punch, What-
  • O-Melon (Watermelon), Pixie Dust, Peachy Oh, Red Fish Candy, Sour
  • Green Apple

Nutritional Profile and Benefits

For obvious reasons, one scoop of Dr. Jekyll (9.7g) is larger than a scoop of Mr. Hyde (7.6g).

In each scoop, you get 25mg of niacin in both products, while Dr. Jekyll also contains 35mg of calcium.

Caffeine is one ingredient that doesn’t come close in these two products. 

Mr. Hyde Nitro X is packed with caffeine (420mg), which is equivalent to over four cups of coffee, but in a stronger and purer form. On the other hand, Dr. Jekyll contains only 100mg of caffeine for less crash and sufficient focus.

white cups of coffee held by a couple

The overall caffeine content in Mr. Hyde is hyped again with other stimulants, like theacrine (25mg), yohimbe bark extract (3mg). But, Dr. Jekyll contains only an extra 25 grams of theacrine (TeaCrine).

Besides the stimulants, they have the same dose of beta-alanine (2.5g) and creatine hydrochloride (1g) for endurance and strength. They also have the same dose of choline bitartrate (500mg).

Dr. Jekyll is better dosed for muscle pumps with ingredients like l-citrulline aspartate (1.5g), arginine silicate (500mg), l-norvaline (100mg) and glycerol monostearate (1.5g). 

The few pump ingredients in Mr. Hyde are underdosed, having only 500 milligrams of l-citrulline aspartate and 500 milligrams of arginine silicate (Nitrosigine).

Mr. Hyde also contains 25mg of gamma-aminobutyric acid.

Benefits & Effectiveness

Mr. Hyde has more active ingredients than Dr. Jekyll but is short of one vitamin – Calcium.  Dr. Jekyll contains 36mg of calcium which is 3% of your daily need.

Niacin is an essential B-vitamin that can help blood flow, and both products give you about 156% of your daily intake with a whopping dose of 25 grams.

For the active ingredients, Mr. Hyde has got fifteen (15), to be exact, most of which are stimulants.

I’ll make comparisons where necessary with special emphasis on the caffeine and stimulant ingredients.

Mr. Hyde and Dr. Jekyll Caffeine and Stimulants

Hyde’s 300 grams of caffeine anhydrous, 70 milligrams di-caffeine malate, and 50 milligrams of caffeine citric acid blend (5mg caffeine only) alone gives you an INSANE amount of energy in the gym.

Now if you add the other complementary stimulants – 25 milligrams of theacrine (TeaCrine) 25mg, and 5 milligrams of yohimbe root extract – which makes too strong for even an average caffeine taker. 

The theacrine is a standard dose, and thankfully, yohimbe is underdosed as it can pose serious potential side effects.

Mr. Hyde then adds a minuscule dose of gamma-aminobutyric acid (25mg), which helps relaxation and sleep. An effective dose of GABA is between 2-3g, but I guess ProSupps doesn’t want you sleeping in the gym. Even at that, I doubt that 25 milligrams will completely ease the effects of the high amount of stimulants.

In any case, you’ll get an insane amount of energy but also possibly a big crash after your workout.

One word of caution, never try Mr. Hyde if you are caffeine sensitive or close to your bedtime.

On the other hand, Dr. Jekyll contains 125mg of caffeine. This includes caffeine anhydrous (100mg) and theacrine (25mg), which will give you a desirable amount of energy but nothing insane.

It’s the perfect amount if you aren’t so tolerant to caffeine or if you want to cut back on your caffeine intake. Dr. Jekyll also has a stimulant-free option if you don’t want any caffeine in your pre-workout.

Energy and Endurance Ingredients

Choline Bitartrate

Choline bitartrate is an ingenious addition by ProSupps since 94% of adults lack this substance. Choline improves cognition and vigor

The good thing is, both products contain a clinically effective dose of choline (500mg).

Beta Alanine

If you aren’t a newbie to pre-workouts, you must have felt tingly or a face-biting sensation at a point in time. This effect is harmless, by the way.

active couple biking

That’s beta-alanine. It’s a natural amino acid that boosts endurance during aerobic and anaerobic exercise by building up carnosine levels.

The two products contain 2.5g of beta-alanine, which is a pretty good dosage, but fail to pair it with taurine. This is a minor issue, since beta-alanine may cause taurine deficiency,

Creatine Hydrochloride

Mr. Hyde and Dr. Jekyll both contain 1g of creatine hydrochloride, which is not just an effective dose, but also a better type of creatine.

Creatine helps your muscles contract better, giving you more reps in your strength exercises.

The creatine in the products are artificial, so it's vegan-friendly for those that don’t mind the synthetic source.

Muscle Pump Ingredients

Dr. Jekyll leads the way between the two, when it comes to giving you muscle pumps.

It contains 1.5 grams of L-citrulline aspartate, which is three times the amount in Mr. Hyde but have the same dose of arginine silicate supplementation (Nitrosigine 500mg). 

couple holding battle ropes

This combination boosts nitric oxide, which gives you better muscle pumps by increasing oxygen and nutrient flow to your blood vessels.

The dose of l-citrulline and arginine Mr. Hyde is underdosed, which isn’t likely to produce any noticeable effects.

Many people, however, might prefer citrulline malate for its two-fold effects – pumps and endurance.

The other pump booster in Dr. Jekyll is l-norvaline (100mg), which helps continued production of nitric oxide when arginine limits the amount you can make. It also contains an effective dose of glycerol monostearate which boosts muscle pump by increasing water amounts in the blood.

When you combine the l-citrulline, arginine, l-norvaline with glycerol, you can only get crazy muscle pumps.

The Other Ingredients

The “other ingredients” in both products are natural and artificial flavors, coloring, and additives like, malic acid, citric acid, silicon dioxide and sweeteners.

Since some people have issues with artificial sweeteners, they both contain sucralose and acesulfame potassium, so you can check if you are cool with it.

Taste and Mixability

Mr. Hyde and Dr. Jekyll both taste really delicious, and I’ll take either of them even as a recreational drink.

What I’ve noticed in every Jekyll and Hyde pre-workout review in the section about taste is that they confuse taste for mixability or consistency.


The two products don’t have the best consistency you’ll hope for in a pre-workout. They will mix up well enough in a glass of water, but flaky powdery particles still floating around in the mixture.

Now, these particles give a powdery feel when you take your PWO, which isn’t necessarily its taste.

So, they taste delicious, but not without leaving a slightly chalky or powdery feel in the mouth.

If you can get past the chalky/powdery feel, Dr. Jekyll and Mr. Hyde are tasty and flavorful pre-workouts.

One last thing, the sweet taste is as a result of artificial sweeteners, like acesulfame potassium and sucralose.

Side Effects and Safety

I’ll start off with a similar side effect you can get from Mr. Hyde NitroX. One scoop can get your skin tingly or itchy during your training. This effect is harmless, and some folks actually like the feeling.

That said, there is a big chance you can get jittery, insomnia, or even a crash after using a scoop (1/2 scoop) of Mr. Hyde. Its caffeine and stimulants content is off the chart. I’ll advise you not to take this product if you aren’t a stim-junkie or very tolerant of caffeine. 

With Dr. Jekyll, this shouldn’t be an issue if you aren’t seriously sensitive to caffeine.

The l-norvaline in Dr. Jekyll, though not fully proven, poses a long term risk of brain damage from prolonged use.

Also, both products shouldn't be used for weight loss or if you are 15 pounds overweight. If you have any health condition, check the warning label to see if you can use the PWO. For one, it is not safe for folks under 18, pregnant women, and nursing moms.

One safety precaution you should always follow with pre-workouts is to avoid double doses. And you don’t want to try this with Mr. Hyde for any reason.

For more options and more thorough evaluation, let me give you some other choices of the best pre-workout supplements in the market today, to give you a broader perspective, in an article we published in the recent past.

Can You Use Mr. Hyde and Dr. Jekyll Pre-Workouts Together?

I wonder who would want to do this, but yes, you can combine both!

Anyway, if you are a caffeine beast and want the workout of your life, I’ll still advise you to start off with ½ a scoop of Hyde before taking full scoops to test your tolerance.

Note that, a full scoop ½ of the measuring spoon, so 1/4 of the spoon makes a half serving.

How Much Do They Cost?

The price of these pre-workouts varies by, flavor, and amount of servings. I’ll use the most expensive flavors in this review to give you an idea of the most you can pay for Mr. Hyde or Dr. Jekyll.  

For Dr. Jekyll, a tub of 30 servings in the Blue Razz Popsicle flavor costs $27.49, but you can pay as little as $18.25 for the What-O-Melon flavour.

That’s about 92 cents per serving for Blue Razz Popsicle and 61 cents per serving for What-O-Melon. It’s a very good deal for the quality of the effects and ingredients you get from the product.

Mr. Hyde comes in two sizes: 15 and 30 servings.

Its Sour Green Apple flavour costs $26.16 for a tub of 30 servings. That’s about $1 per serving, which is the average price for a pre-workout.

A tub of 15 servings of Mr. Hyde Blue Razz Popsicle costs $14.80, which is still about a buck per serving. If you are on a budget, you can settle for the What-O-Melon flavour at $10.89 (72 cents/serving).


Mr. Hyde vs C4

A lot of people have made comparisons with these two products. I don’t see a reason why, since they don’t work the same way.

Cellucor C4 contains 150mg of caffeine, which is only a fraction of the amount in Mr. Hyde. It also has a proprietary blend, Explosive Energy Blend, which you won’t find in Mr. Hyde.

What Mr. Hyde doesn’t have, however, except Niacin, is an abundance of vitamins, like Vitamin C, B12, B9 (folic acid), and B6.

Also, they are closely priced, with both costing about $1 per serving.

Legion Pulse Stim-Free Pre Workout

This a better, but pricier alternative to Dr. Jekyll if you are sensitive to caffeine and want massive muscle pumps.

Legion Pulse contains double the amount of the key ingredients in Dr. Jekyll for pumps and endurance. It contains 3.6 grams of CarnoSyn beta-alanine (better quality than the one found in Dr. Jekyll), 8 grams l-citrulline dl-malate 2:1, and 2.5 grams of betaine anhydrous.

It costs $40 for a tub of 21 servings (2 scoops per serving), so you get about 40 servings if you take a scoop each serving. At 21 servings, it costs $1.90, which is relatively pricey - but one of the best on the market in terms of quality.

Now, before we get down below, here's one more pre workout product; the 4 Gauge Pre-workout drink that you may also want to see the review...  And you might also want to check our Ghost Legend review to add to your list of alternatives.

Mr. Hyde Nitrox Pros and Cons 


  • Massive caffeine content for unthinkable focus and energy
  • A reasonable dose of beta-alanine and creatine for more reps
  • No proprietary blend
  • Has a delicious taste
  • Good price deal


  • Subpar dose of l-citrulline and arginine
  • High chance of a post workout crash
  • Gritty feel in the mouth
  • Contains Sucralose

Dr. Jekyll Pros and Cons 


  • Unrivalled muscle pumps
  • A good dose of beta-alanine and creatine for endurance
  • Mild caffeine content with TeaCrine for better focus
  • Has a delicious taste
  • No proprietary blend
  • Can be used for morning or evening workouts
  • Has a stim-free version
  • Good value for money


  • Contains sucralose
  • Doesn’t mix too well
  • Chalky or powdery feel in the mouth


In the end, it all boils down to what you are looking for in a pre-workout.

If you are caffeine tolerant and want something VERY potent, go for Mr. Hyde. On the other hand, if you aren’t caffeine tolerant and you want a mild energy boost and massive pumps, go for Dr. Jekyll.

In the case that you want both, I’ll say nothing is stopping you from combining them if you can handle up to 500mg of caffeine - or just half the dose of each for a more well-rounded blend.

On a final note, they are both priced well, so all you have to worry about is how much your body can take.

So which personality suits you best - Dr. Jekyll or Mr. Hyde?

Last Updated on July 12, 2020

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